Nobutaka Fujii Selected Research

HIV Fusion Inhibitors

1/2007	Therapeutic potential of the chemokine receptor CXCR4 antagonists as multifunctional agents.
1/2007	Development of low molecular weight CXCR4 antagonists by exploratory structural tuning of cyclic tetra- and pentapeptide-scaffolds towards the treatment of HIV infection, cancer metastasis and rheumatoid arthritis.
7/2004	Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent.

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Nobutaka Fujii Research Topics

Disease

47	Neoplasms (Cancer) 12/2020 - 04/2002
22	Infections 09/2016 - 03/2002
21	Neoplasm Metastasis (Metastasis) 10/2012 - 07/2002
7	Acquired Immunodeficiency Syndrome (AIDS) 10/2008 - 02/2003
6	Rheumatoid Arthritis 03/2012 - 07/2004
6	Pancreatic Neoplasms (Pancreatic Cancer) 03/2009 - 04/2002
5	Breast Neoplasms (Breast Cancer) 01/2015 - 08/2003
4	Carcinoma (Carcinomatosis) 07/2015 - 07/2002
4	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 10/2012 - 11/2003
3	HIV Infections (HIV Infection) 03/2012 - 12/2005
3	Urinary Bladder Neoplasms (Bladder Cancer) 10/2011 - 09/2010
3	Leukemia 10/2008 - 09/2005
2	Inflammation (Inflammations) 05/2015 - 11/2008
2	Hypoxia (Hypoxemia) 04/2015 - 05/2010
2	Virus Diseases (Viral Diseases) 11/2012 - 09/2012
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2011 - 02/2009
2	Glioma (Gliomas) 12/2010 - 03/2008
2	Experimental Arthritis 10/2008 - 07/2004
2	Melanoma (Melanoma, Malignant) 10/2008 - 12/2005
2	Hypersensitivity (Allergy) 10/2008 - 07/2004
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2007 - 01/2007
1	Body Weight (Weight, Body) 08/2020
1	AIDS-Related Complex (ARC) 08/2020
1	Disease Progression 12/2018
1	Pathologic Processes 01/2018
1	Communicable Diseases (Infectious Diseases) 01/2016
1	Subacute Sclerosing Panencephalitis (SSPE) 01/2016
1	Measles 01/2016
1	Ovarian Neoplasms (Ovarian Cancer) 07/2015
1	Hepatocellular Carcinoma (Hepatoma) 05/2015
1	Anemia 05/2015
1	Hemochromatosis (Bronze Diabetes) 05/2015
1	Sarcoma (Soft Tissue Sarcoma) 04/2015
1	Fibrosis (Cirrhosis) 01/2015
1	Immune System Diseases (Immune Disorders) 08/2012
1	Noninfiltrating Intraductal Carcinoma (DCIS) 01/2012
1	Hypertrophy 01/2012
1	Rib Fractures (Rib Fracture) 01/2012

Drug/Important Bio-Agent (IBA)

19	Peptides (Polypeptides)IBA 01/2016 - 03/2002
15	Chemokine ReceptorsIBA 01/2018 - 03/2002
12	T140 peptideIBA 09/2010 - 03/2002
11	KisspeptinsIBA 08/2020 - 02/2004
9	Proteins (Proteins, Gene)FDA Link 01/2016 - 01/2008
8	Pharmaceutical PreparationsIBA 01/2015 - 02/2003
8	LigandsIBA 03/2014 - 08/2003
7	Chemokine CXCL12IBA 01/2018 - 11/2003
6	Antiviral Agents (Antivirals)IBA 01/2016 - 12/2007
5	ChemokinesIBA 12/2018 - 02/2003
5	CXCR4 Receptors (CXCR4 Receptor)IBA 08/2012 - 11/2003
4	6H- 6- imino- (2,3,4,5- tetrahydropyrimido)(1,2- c)- (1,3)benzothiazineIBA 04/2015 - 09/2012
4	Small Interfering RNA (siRNA)IBA 01/2015 - 05/2010
3	Gonadotropin-Releasing Hormone (GnRH)FDA Link 08/2020 - 06/2007
3	Anti-HIV Agents (AIDS Drugs)IBA 10/2015 - 06/2004
3	IminesIBA 04/2015 - 11/2012
3	DiaminesIBA 01/2015 - 01/2013
3	Polysorbates (PSML)FDA Link 01/2015 - 01/2013
3	4- fluorobenzoyl- Arg- Arg- Nal- Cys- Tyr- Cit- Lys- Lys- Pro- Tyr- Arg- Cit- Cys- Arg- NH2 (S-S bridged)IBA 10/2012 - 01/2009
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 03/2012 - 07/2002
3	IntegrinsIBA 01/2012 - 11/2003
3	4-fluorobenzoyl-TN-14003IBA 10/2008 - 08/2003
3	HIV Fusion InhibitorsIBA 01/2007 - 07/2004
2	CXCR ReceptorsIBA 01/2018 - 06/2013
2	KinesinsIBA 07/2015 - 03/2011
2	pyrimidineIBA 04/2015 - 04/2015
2	Anti-Retroviral Agents (Antiretroviral Agents)IBA 04/2015 - 11/2012
2	hydroxide ionIBA 01/2015 - 01/2013
2	N- (2- (2- (2- hydroxyethylamino)ethylamino)ethyl)cholesteryl- 3- carboxamideIBA 02/2013 - 01/2013
2	DNA (Deoxyribonucleic Acid)IBA 02/2013 - 01/2013
2	Biomarkers (Surrogate Marker)IBA 01/2012 - 03/2009
2	NitrosaminesIBA 10/2011 - 09/2010
2	CXC ChemokinesIBA 10/2011 - 09/2010
2	Antineoplastic Agents (Antineoplastics)IBA 03/2011 - 09/2010
2	polyglutamineIBA 01/2011 - 02/2009
2	TC14012IBA 12/2010 - 02/2003
2	Glycoproteins (Glycoprotein)IBA 07/2009 - 03/2006
2	CalciumIBA 03/2006 - 11/2005
1	Bone SubstitutesIBA 12/2020
1	Dynorphins (Dynorphin)IBA 08/2020
1	Neurokinin BIBA 08/2020
1	X-Linked Inhibitor of Apoptosis ProteinIBA 01/2019
1	CytokinesIBA 12/2018
1	VaccinesIBA 01/2016
1	carbazoleIBA 07/2015
1	LactamsIBA 07/2015
1	HepcidinsIBA 05/2015
1	IronIBA 05/2015
1	Carbonic Anhydrase IXIBA 04/2015
1	LuciferasesIBA 04/2015
1	coibamide AIBA 01/2015
1	Liposomes (Liposome)IBA 01/2015
1	CholesterolIBA 01/2015
1	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 03/2014
1	LipidsIBA 02/2013
1	5-dimethylamilorideIBA 11/2012
1	PeptidomimeticsIBA 08/2012
1	IndiumIBA 01/2012

Therapy/Procedure

11	Drug Therapy (Chemotherapy) 07/2015 - 06/2004
4	Therapeutics 09/2016 - 04/2002
3	Subcutaneous Injections 10/2011 - 08/2003
1	Orthopedic Procedures 12/2020